Biaxin xl
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The pharmacokinetics of clarithromycin depends on the dose. After oral clarithromycin is rapidly absorbed, reaching maximum plasma concentrations in 2-3 hours. The biological availability of about 55%. After absorption of clarithromycin penetrates into most tissues, the placental barrier in breast milk. Not penetrate the blood-entsefalychnyy barrier. Since the protein binds to 65-75% of clarithromycin. Metabolized by the liver to form the main metabolite 14-hidroksyklarytromitsynu having the same, or 1 - 2 orders of magnitude less (depending on the type of microorganism) antimicrobial activity than unmodified material.
Biaxin xl
The half-life: when taking 250 mg - 3-4 hours, 500 mg - 5-7 hours (for unchanged substance - 5.3 hours for the active metabolite - 7.7 hours). Since the body is excreted as unchanged and as metabolites in almost equal parts of urine and faeces. In patients with functional insufficiency of liver or kidney moderate during half output increases. The main pathway - enzymes cytochrome CYP 3A (clarithromycin both a substrate and inhibitor of CYP 3A enzymes, the most important of which is CYP 3A4).
Biaxin xl
Infections caused by clarithromycin susceptible microorganisms: infections of the upper respiratory tract and upper respiratory tract (laryngitis, pharyngitis, tonsillitis and sinusitis); infections of the lower respiratory tract (bronchitis, bacterial pneumonia, SARS); infections of skin and soft tissue (folliculitis, abrasions, impetiho, wound infection); infections caused by Mycobacterium avium, Chlamydia trachomatis, Helicobacter pylori, Ureaplasma urealyticum.
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| Category: buy biaxin xl online | Added by: Dnister (22.11.2016)
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