In conducting studies revealed a slight amount of ibuprofen in breast milk. NSAIDs are not recommended for use during breast-feeding.
Children. Do not use in children weighing <20 kg and under the age of 6 years.
Ability to influence the reaction rate when driving or operating other machines. Provided the application doses according to the recommended duration of treatment and the drug has no effect on the reaction rate when driving or operating other mechanisms. Patients experiencing dizziness, drowsiness, disorientation or visual disturbances when using NSAIDs should avoid driving vehicles or using machinery.
ibuprofen, like other NSAIDs, should not be used in combination with acetylsalicylic acid (it may increase the risk of adverse reactions, unless aspirin at a dose not exceeding 75 mg / day, prescribed by a doctor) and other NSAIDs, including selective inhibitors COX-2.
Caution should be used ibuprofen in the following combinations:
with antihypertensive agents (ACE inhibitors and angiotensin II) and diuretics: NSAIDs may reduce the effect of diuretics and other antihypertensive drugs. In some patients with impaired renal function (patients with dehydration or elderly patients with compromised renal function) the simultaneous use of ACE inhibitors or angiotensin II antagonists and agents that inhibit COX, may result in further deterioration of renal function, including possible acute renal failure, which is usually It is reversible.
Therefore, such combinations should be used with caution, especially in the elderly. If necessary, long-term treatment should be carried out adequate hydration of the patient and consider monitoring renal function at the beginning of combined treatment and at regular intervals thereafter. Diuretics can increase the risk of nephrotoxic effects of NSAIDs. Concomitant use of potassium-sparing diuretics with ibuprofen can lead to hyperkalemia (potassium is recommended to control the level in the blood plasma).
With anticoagulants. NSAIDs may enhance the therapeutic effect of anticoagulants such as warfarin.
With antiplatelet agents and selective serotonin inhibitors: may increase the risk of gastrointestinal bleeding.
|Category: ibuprofen tablets | Added by: Dnister (25.11.2016)
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