Ibuprofen - drug, NSAIDs, derivatives of propionic acid has analgesic and antipyretic effect.
The mechanism of action and safety profile of ibuprofen is well researched, clinically tested its effectiveness, and therefore the drug is on the list of essential medicines of the World Health Organization.
2 General information
7 Side Effects
Properties [Ed. • Ed. code]
White or off-white crystalline powder, practically insoluble in water, soluble in organic solvents (ethanol, acetone). There is a racemic mixture of R - and S- enantiomers.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It has anti-inflammatory, analgesic and antipyretic activity moderate. The basis of the mechanism of action plays an important role inhibiting the biosynthesis of prostaglandins E and F at central and at the peripheral level. There is evidence of the stimulating effect of ibuprofen on the formation of endogenous interferon and its ability to exert immunomodulatory effects and improve the rate of non-specific resistance of the organism.
Ibuprofen works in rheumatoid arthritis is more pronounced in the early stages of inflammation without abrupt changes in the joints. By the power of action it slightly inferior ortofen, indomethacin, but better tolerated.
Used for the treatment of rheumatoid arthritis, deforming osteoarthritis, ankylosing spondylitis and in various forms of joint and extraarticular rheumatic diseases and pain in certain inflammatory lesions of the peripheral nervous system.
Recently ibuprofen are increasingly used as antipyretics for the symptomatic treatment of febrile conditions in infectious diseases (influenza, SARS and so on. Al.), Including children. However, according to the order of from MZiSR 30.12.06, children under 3 months, ibuprofen should be used on a doctor's prescription because of its safety profile is inferior paracetamol, which operates only at the central level. In addition, ibuprofen should not be used in children with asthma, the chronically ill children, and in patients with gastritis and ulceration of the gastrointestinal tract.
The symposium pediatricians in pain (Vancouver, Canada, August 2006), the manufacturing company of the original ibuprofen found that yields efficacy of acetaminophen at therapeutic doses and the recommendation of the World Health Organization is the second drug of choice for treatment of fever and pain in children (paracetamol was and remains the drug of first choice for treatment of fever and pain in adults and children from 2 months. life).
|Category: ibuprofen tablets | Added by: Dnister (25.11.2016)
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