| Ibuprofen 200mg price
Nonsteroidal anti-inflammatory drug (NSAID) has analgesic, antipyretic and anti-inflammatory action due to indiscriminate blockade of both forms of the enzyme cyclooxygenase (COX-1 and COX-2). Makes inhibiruvalnyy effect on prostaglandin synthesis (Pg). Analgesic effect is most pronounced with inflammatory pain. Like all NSAIDs, ibuprofen exhibits antiplatelet activity.
Pharmacokinetics
Well absorbed from the gastrointestinal tract. The absorption decreases slightly while taking the drug after meals. TCmax when taken on an empty stomach - 45 minutes, when taken after a meal - 1.5-2.5 g, synovial fluid - 2-3 grams (which creates a greater concentration than in plasma). How to plasma proteins by 90%. Presystemnomu postsystemnomu exposed and metabolism in the liver. After absorption of about 60% pharmacologically inactive form of R- ibuprofen slowly transformed into an active S- form. In the metabolism of the drug involved isoenzyme CYP2C9. It has a biphasic elimination kinetics of T1 / 2 2-2.5 grams (to retard form - 12 g). Excreted by the kidneys (unchanged less than 1%) and to a lesser extent - the bile.
Ibuprofen 200mg price
Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, juvenile chronic, psoriatic arthritis, low back pain, neurological amiotrofiya (illness Personeydzha Turner), arthritis in SLE (in the complex therapy), gouty arthritis (acute attack of gout preferred fast dosage forms) , ankylosing spondylitis (ankylosing spondylitis).
Ibuprofen 200mg price
Pain: myalgia, arthralgia, ossalhiya, arthritis, sciatica, migraine, head (including the menstrual syndrome) and tooth pain for cancer, neuralgia, tendonitis, tenosynovitis, bursitis, neuralgic amiotrofiya (illness Personeydzha Turner), posttraumatic and postoperative pain, accompanied by inflammation.
Algodysmenorrhea, inflammation in the pelvis, including adnexitis, childbirth (as analgesic and tocolytic agent).
Feverish syndrome with "cold" and infectious diseases.
Designed for symptomatic therapy reduce pain and inflammation at the time of use, the progress of the disease is not affected.
Contraindication
Ibuprofen 200mg price
Hypersensitivity, erosive and ulcerative diseases of the gastrointestinal (including gastric ulcer and 12 rings ulcer exacerbation of ulcerative colitis, peptic ulcers, Crohn's disease - ulcerative colitis), complete or incomplete combination of bronchial asthma, recurrent nasal polyposis, and paranasal sinuses and intolerances ASA or others. NSAIDs (including history), blood coagulation disorders (including hemophilia, prolongation of bleeding time, a tendency to bleeding, hemorrhagic diathesis), active gastrointestinal bleeding; severe renal insufficiency (CC less than 30 ml / min), craniocerebral trauma, increased intracranial pressure, intracranial hemorrhage, diseases of the optic nerve, violations of color vision, amblyopia, scotoma, progressive renal disease, severe hepatic impairment or active liver disease, condition after coronary bypass, confirmed hyperkalemia, inflammatory bowel disease, the third trimester of pregnancy (category B in the first two and D in the third trimester), children under 2 years (drops for use internally), 3 months (suspension for use internally for children) to 6 years (tablets, coated) to 12 (capsules, extended release).
|