Corticosteroids may increase the risk of adverse reactions from the gastrointestinal tract.
Cardiac glycosides during concomitant use of ibuprofen may exacerbate cardiac failure, reduce glomerular filtration rate; glycosides level in blood plasma can be increased.
Cyclosporins. There are some data on possible interaction of drugs that may increase the risk of nephrotoxicity.
Mifepristone. Should not take NSAIDs for 8-12 days after administration of mifepristone, it can reduce the effect of mifepristone.
Tacrolimus. Increased risk of nephrotoxicity.
Lithium and methotrexate. There is evidence of the potential of lithium and improving the blood plasma of methotrexate.
Zidovudine. There is evidence of increasing risk of haemarthrosis and hematoma in HIV-infected patients receiving concomitant treatment with zidovudine and ibuprofen.
We know about the increased risk of haematological toxicity with concomitant use of zidovudine and NSAIDs.
Quinolone antibiotics. Concomitant use can increase the risk of seizures.
Caffeine. In an application enhanced analgesic effect of ibuprofen.
Phenytoin and sulphonylureas: may increase the effect.
use in children doses> 400 mg can cause symptoms of intoxication. In adults the dose effect is less pronounced. T? In overdose is 1.5-3 hours.
Symptoms of intoxication: the majority of patients who participated in clinical studies, the use of a significant amount of NSAID induced a nausea, vomiting, epigastric pain, or very rarely - diarrhea. It may cause noise in the ears, headache, and bleeding from the digestive tract. In more severe poisoning may be toxic CNS as drowsiness, and sometimes - the nervous excitement and disorientation or coma. Sometimes patients having convulsions. In severe poisoning can occur and metabolic acidosis, hyperkalemia, prothrombin index can be increased, perhaps by influencing blood coagulation factors. Acute renal failure may occur and liver damage, hypotension, respiratory distress and cyanosis. Patients with asthma may occur exacerbation of the disease course.
The treatment may be symptomatic, and additional, and also include the release of the respiratory tract and symptoms of cardiac monitoring and vital signs until the normalization condition. It recommended oral administration of activated charcoal for 1 hour after the application of potentially toxic amounts of the drug. If ibuprofen has already been absorbed, can be administered alkaline r-ry to accelerate the excretion in the urine.
in the original packaging at a temperature not exceeding 25 ° C.
|Category: ibuprofen tablets | Added by: Dnister (25.11.2016)
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