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Name: VIAHRA® | Search VIAHRA® pharmacies → INN: Sildenafil Manufacturer: Pfizer Pi. Gee. Hem, France Dosage form: coated tablets Product: coated tablets, 50 mg number 1, number 4 Active substance: 1 tablet contains: 70.225 mg sildenafil citrate, which is equivalent to 50 mg of sildenafil Inactive ingredients: microcrystalline cellulose, calcium hidrohenfosfat (anhydrous), croscarmellose sodium, magnesium stearate, Opadry II blue (OY-LS-20921), Opadry II clear (YS-2-19114-A) Pharmacotherapeutic group: Drugs that stimulate spinal cord functions primarily Indication: Treatment of erectile dysfunction, defined as the inability to achieve and maintain penile erection necessary for successful intercourse .For Viahry® effective action requires sexual stimulation. Shelf life: 5r. Registration Certificate Number: UA / 0313/01/02 The validity of the certificate: from 22.07.2008 to 22.07.2013 The validity of the registration certificate expired. Search data on drug registration VIAHRA® AT code: G04BE03 MOH: 1075 on 30.12.2009 Prices for VIAHRA® pharmacies Share ... Save   Instructions for use VIAHRA® INSTRUCTION medical use of the drug VIAHRA® (VIAGRA®) Storage. Active substance: 1 tablet contains 70.225 mg of sildenafil citrate, which is equivalent to 50 mg of sildenafil; 1 tablet contains 140.450 mg of sildenafil citrate, which is equivalent to 100 mg of sildenafil; Additional ingredients: microcrystalline cellulose, calcium hydro phosphate (anhydrous), croscarmellose sodium, magnesium stearate, Opadry II blue (OY-LS-20921), Opadry II clear (YS-2-19114-A). Dosage form. Coated tablets. Pharmacological group. Drugs used in erectile dysfunction. Sildenafil. ATC Code G04B E03. Clinical characteristics. Indication. Treatment of erectile dysfunction, defined as the inability to achieve and maintain penile erection necessary for successful sexual intercourse. For effective action Viahry® desired sexual arousal. Contraindication. Application Viahry® contraindicated in patients with known hypersensitivity to the active substance or any excipient. Through the influence of the exchange of nitric oxide / cGMP, sildenafil enhances the hypotensive effect of nitrates in their single or prolonged use, so it is a common destination with nitric oxide donors, organic nitrates or organic nitrites in any form continuously or periodically contraindicated. For the treatment of erectile dysfunction, including sildenafil, should not use patients for whom sexual activity is not desirable (eg, patients with severe heart disease such as unstable angina or severe heart failure). Reception Viahry® contraindicated in patients who have lost vision in one eye because of nearterialnu anterior ischemic optic neuropathy, regardless of whether it happened because the previous method inhibitor FDE5 or not. Safety of sildenafil has not been studied in these subgroups, and therefore these patients its use is contraindicated in: patients with severely impaired hepatic function, with hypotension (blood pressure <90/50 mm Hg. In.) With the recently stroke or myocardial infarction and known hereditary degenerative retinal disorders such as retinitis pigmentosa (a minority of these patients have genetic retinal disease fosfodyesteraz). Dosage and administration. Tablets are intended for oral administration. To implement the necessary effect cyldenafilu sexual arousal. Applications adults. The recommended dose for adults is 50 mg, which shall, if necessary, for about 1 hour before sexual activity. Given the efficacy and tolerability, the dose may be increased to 100mg or decreased to 25mg. The maximum recommended dose is 100 mg. The maximum recommended frequency of admission - once a day. Viahry® activity can be detected through a longer period when taken with food, compared with taking an empty stomach. Applications patients with impaired renal function. Patients with renal insufficiency mild to moderate severity (creatine clearance well is 30 - 80 ml / min) dosing regimen does not change. Because patients with severe renal impairment (creatine clearance well <30 ml / min), sildenafil clearance was reduced, the drug should be started at a dose of 25 mg. Applications patients with impaired hepatic function. Since patients with hepatic impairment reduced clearance of sildenafil, such as cirrhosis, the drug should be started at a dose of 25 mg. Use in patients using other treatments. Given the degree of interaction in patients who receive concomitant therapy ritonavir is recommended not to exceed a maximum single dose of 25 mg sildenafil within 48 hours. The starting dose of 25 mg should be recommended in patients receiving concomitant treatment inhibitors of CYP3A4 (eg, erythromycin, saquinavir, ketoconazole, itraconazole). To reduce the risk of postural hypotension should achieve stabilization of patients on background therapy of alpha-blockers for use Viahry®. Furthermore, it should start with the smallest of the drug dose. The use of children. Viahra® not indicated for use by persons under 18 years. Application elderly patients. For elderly patients change the dosage is needed. Adverse reactions. Side effects were transient, mild to moderate. During the study the frequency and severity increased with increasing dose. The nature of side effects in studies of variable dose, which largely reflects the recommended dosage regimen, was similar to the fixed-dose studies. The most common side effects were headache and flushing. Very common side displays - Frequency more than 1/10: Nervous system disorders - headaches. Disorders of the cardiovascular system - vasodilatation (hot flushes). Frequently - frequency of 1 / 100-1 / 10: Nervous system disorders - dizziness. Visual disturbances - abnormal vision (blurred vision, sensitivity to light) hromatopsiya (moderate, transient, especially color vision). Disorders of the cardiovascular system: palpitatsiya (feeling heartbeat). Disorders of the respiratory system - rhinitis (nasal congestion). Disorders of the digestive tract - dyspepsia. Using the drug in doses higher than recommended, adverse events were similar, but there often. The use of sildenafil did not affect the incidence of myocardial infarction and mortality rate from cardiovascular disease. In the period after the registration or had observed unusual reactions common in patients receiving the drug: Immune system - hyper sensitivity reactions (including skin rash); nervous system - seizure, recurrent epileptic seizure; Cardiovascular - tachycardia, hypotension, syncope, epistaxis; digestive tract - vomiting; visual disturbances - pain in the eyes, redness of the eyes; reproductive system - prolonged erection and / or priapism. generic viagra super active Overdose. In studies in healthy volunteers at one time taking the drug at doses up to 800 mg of adverse events were similar to those observed at lower doses Viahry®, but their frequency of occurrence and severity increased. In cases of overdose should, if necessary, apply symptomatic therapy. It should be noted that dialysis can not speed up the withdrawal of the drug, because sildenafil tightly bound to plasma proteins and not eliminated in the urine. Features of the application. To diagnose erectile dysfunction, determine potential causes of disease and appointment of adequate treatment must carefully study the history of the patient and conduct a thorough medical examination. For the effectiveness of the Viahry® requires sexual stimulation. Associated with sexual activity a risk because of the possibility of heart attack. So, before you start any course of treatment for erectile dysfunction, your doctor should check the status of cardiovascular patients. Drugs designed to treat erectile dysfunction, should not be used in patients for whom sexual activity is desirable. In the period after the introduction of the drug in broad medical practice reports of serious cardiovascular complications that time coincides with taking sildenafil. These include myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage and transient ischemic attack. Most, but not all, of these patients had previous cardiovascular risk factors. The overwhelming number of cases observed during or immediately after sexual load a small part - in a short period after taking sildenafil without sexual activity. Other cases occurred due to hours or days after using sildenafil and sexual activity. Thus, it is impossible to establish a direct relationship of these cases with the use of sildenafil, sexual activity, with concomitant cardiovascular diseases, the combination of these factors or other factors. generic viagra super active In healthy volunteers at one time taking sildenafil doses up to 100 mg no clinically significant changes in ECG. Average maximum decrease in systolic blood pressure in a horizontal position after oral administration of the drug at a dose of 100 mg was 8.34 mm Hg. Art. The corresponding change in diastolic pressure in horizontal position was 5.3 mmHg. Art. Lower than usual, but briefly, reduced blood pressure in patients simultaneously taking nitrates. Studies showed sildenafil systemic Vasodilator action that resulted in transient reduction in blood pressure. This effect has little importance or do not lead to any consequences in most patients. However, the appointment of sildenafil physician should carefully weigh the risk of adverse manifestations Vasodilator action in patients with certain underlying medical conditions, especially against the background of sexual activity. Hypersensitivity to vasodilators observed in patients with left ventricular obstruction (aortic stenosis, obstructive hypertrophic cardiomyopathy), as well as multiple system atrophy symptoms, occurring in isolated cases, manifested grave violation autonomous control blood pressure. Viahra® 100 mg once daily orally in patients with severe heart disease (stenosis> 70% at least one coronary artery) reduces in average systolic pressure and diastolic pressure of rest by 7% and 6% respectively compared to baseline . The average pulmonary systolic pressure decreased by 9%. Sildenafil had no any effect on cardiac output and blood flow in the coronary arteries stenozovanyh, due to improvement (approximately 13%) adenosine-stimulated blood flow reserve (coronary artery stenosis with and without). In patients with erectile dysfutsiyeyu and stable angina who regularly took antianginal medications (except nitrates) and used sildenafil 100 mg once daily orally was observed prolongation tredmil test (19.9 sec .; 95% confidence interval 0, 9-38,9 sec.) and the average time to exercise exacerbation of symptoms of angina 423.6 and 403.7 seconds. compared with placebo. In patients with concomitant hypertension, are both taking two or more antihypertensive drugs, sildenafil at a dose of 100 mg once a day internally improved erections in 71%, increased the number of successful sexual attempts with 62% Number of adverse events was similar compared with those in other populations, taking three or more antihypertensive drugs. In all studies using PDE5 inhibitors, including sildenafil, reported nearterialnu anterior ischemic optic neuropathy (NAION), which is the reason for the reduction or loss of vision. Most of these patients had risk factors such as a reduced ratio of depth / area ( "stagnant disc"), age over 50, diabetes, hypertension, coronary artery disease, hyperlipidemia and smoking. There was no established causal link between PDE5 inhibitors and appearance of NAION. The doctor should warn patients who already have signs NAION, the possible recurrence of NAION. Patients should be advised of the need for immediate medical attention in case of sudden vision loss. In patients with age-retinal degeneration sildenafil 100 mg once a day internally was well tolerated myy and had no clinical effect in the study of visual fuktsiy in tests (visual acuity, grid Amslera, recognize colors, "artificial stream of light" perimeter me on Hamfreya and fotostres). Sildenafil is recommended to be used with caution in patients who are also using alpha-blockers, because in some cases it can cause symptomatic hypotension. In order to minimize the risk of postural hypotension should be to stabilize blood pressure using alpha-blockers for use of sildenafil. It should start to use low doses of sildenafil. In addition, physicians should tell patients what to do in case of symptoms of postural hypotension. Some patients with retinitis pigmentosa congenital genetic defects noted phosphodiesterase retina. No information regarding the safety purpose of sildenafil to patients with retinitis pigmentosa, because this group of patients sildenafil should be administered with caution. Studies of human platelets in vitro indicate that sildenafil increases the effect of sodium nitroprusside antiaggregatory (donator NO). There is no safety information regarding the appointment of sildenafil in patients with a predisposition to bleeding or an acute stomach ulcer, because this group of patients sildenafil should be administered with caution. generic viagra super active Drugs designed to treat erectile dysfunction, should be used with caution in patients with anatomical deformation of the penis (such as angulation, cavernous fibrosis or Peyronie's disease), or in patients who have a disease that can lead to priapism (such as serpopodibno- cell anemia, multiple myeloma or leukemia). The safety and efficacy of combinations of sildenafil with other treatments for erectile dysfunction have not been studied, so the use of such combinations is not recommended. Following oral administration of a single dose of 100 mg sildenafil were not observed any impact on mobility and morphological characteristics of sperm in healthy volunteers. The sudden reduction and hearing loss reported in a small number of cases in postmarketynkovyh studies the application of inhibitors of PDE5 inhibitors, including sildenafil. Most of these patients had risk factors for sudden decrease or loss of hearing. No causality PDE5 inhibitor use and sudden hearing loss and reducing patient is not installed. In the event of sudden decrease or loss of hearing patients should be advised to discontinue use of sildenafil and consult a doctor immediately. Use during pregnancy and lactation. Viahra® not intended for use by women. Children. Viahra® not indicated for use by persons under 18 years. Effects on ability to drive a car or other transport mechanisms. The influence of the drug on the ability to drive and operate machinery have been conducted. Since during clinical trials of sildenafil experienced dizziness and blurred vision, patients should know their reaction to receiving Viahry® before you drive or operate machinery. Interaction with other medicinal products and other forms of interaction. The influence of other drugs on sildenafil. Studies in vitro: Sildenafil metabolism is mediated primarily by cytochrome P450 (CYP), namely its isoforms 3A 4 (the main road) and 2C 9 (minor route). Thus, inhibitors of these isoenzymes may reduce sildenafil withdrawal, and inducers of these isoenzymes may increase its output. Studies in vivo: a population pharmacokinetic analysis of clinical trial demonstrated a reduction in sildenafil clearance while his use of inhibitors of CYP 3A 4 (such as ketoconazole, erythromycin, cimetidine). Cimetidine (800 mg), an inhibitor of cytochrome P450 and a nonspecific inhibitor of CYP3A 4, when receiving concomitant sildenafil 50 mg healthy volunteers sprychynyav increase its plasma concentration by 56%. When administered a single dose of 100 mg Viahry® with erythromycin, a specific inhibitor of CYP 3A 4 (500 mg twice daily 5 days), systemic dose of sildenafil (AUC) increased by 182%. Simultaneous treatment with HIV protease inhibitors saquinavir (1200 mg three times a day), which is also an inhibitor of CYP 3A 4, resulted in an increase in sildenafil Cmax of 140%, AUC - 210%. Viahra® no effect on saquinavir pharmacokinetics. Strong inhibitors of CYP 3A 4, such as ketoconazole and itraconazole, can detect more pronounced effects. Art. Art. Art. Pharmacological properties. Pharmacodynamics. Pharmacokinetics. Pharmaceutical characteristics. Packaging. Of supply. Prescription. Producer. 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