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Biaxin half life
What is this drug, antibiotic or not? The fact that I can not find any information about it ... 16 July Pain in the heart   Hello My daughter (16) Doctor (American) cough and chest pain written out drug Biaxin / Ordered to accept only while eating. This has advised to buy some antacid nibud.Doch these drinks and pills in her mouth constant bitterness. The question is: What kind of drug, antibiotic or not? The fact that I can not find any information about it on the Internet. Thank you. Answer: Yes, Biaxin (Biaxin) is an antibiotic - clarithromycin. Information about him: Clarithromycin Chemical Name: 6-O-methylerythromycin Pharmacological group: Macrolides and azalides. Antibiotic second-generation macrolide. Mode of action - antibacterial (bacteriostatic), antiulcer. Associated with the 50S subunit of the ribosome membrane microbial cells and suppresses protein synthesis. The ingestion quickly and adequately absorbed. Food delays absorption, not significantly affecting bioavailability. After a single dose recorded 2 peak serum concentration. The second peak is due to the ability to concentrate in the gall bladder, followed by gradual or fast release. The plasma is associated with whey proteins (90%). About 20% of the dose immediately oxidized in the liver to form the main metabolite 14-hydroxyclarithromycin (has a pronounced antimicrobial activity against Haemophilus influenzae). The biotransformation catalyzed by the enzyme cytochrome complex P450. It penetrates the body tissue and fluid, creating a concentration 10 times higher than serum levels. T1 / 2 when taking 250 mg - 3-4 hours, 500 mg -. 5-7 hours Return with urine in unchanged form - 20-30%, the rest - in the form of metabolites. Active against intracellular microorganisms (Mycoplasma pneumoniae, Legionella pneumophila, Chlamydia trachomatis and Chlamydia pneumoniae, Ureaplasma urealyticum), gram (Streptosoccus spp., And Staphylococcus spp., Listeria monocytogenes, Corynebacterium spp.) And gram-negative bacteria (Haemophilus influenzae and Haemophilus ducreyi, Moraxella catarrhalis, Bordetella pertussis, Neisseria meningitidis, Borrelia burgdorferi, Pasteurella multocida, Campylobacter spp., Helicobacter pylori), certain anaerobes (Eubacterium spp., Peptococcus spp., Propionibacterium spp., Clostridium perfringens, Bacteroides melaninogenicus), Toxoplasma gondii and all mycobacteria except V.tuberculosis. Biaxin half life Indications: Upper respiratory tract infection and upper respiratory tract (tonzillofaringit, otitis media, acute sinusitis), lower respiratory tract infections (acute bronchitis, exacerbation of chronic bronchitis, bacterial and atypical pneumonia), skin and soft tissue, mycobacterial infection (M.avium complex, M.cansasii, M.marinom, M.leprae), duodenal ulcer and stomach caused by Helicobacter pylori (combination therapy). Contraindications: Hypersensitivity, severe liver disease, porphyria, pregnancy and lactation. Side effects: Nausea, vomiting, change in taste, abdominal pain, diarrhea, pseudomembranous colitis, stomatitis, glossitis, dizziness, headache, restlessness, anxiety, insomnia, nightmares, increased liver enzymes, cholestatic jaundice, allergic (urticaria syndrome Stevens - Johnson et al), and anaphylactoid reactions.. Interaction: Increases blood concentration of drugs metabolized in the liver with the participation of enzymes of the cytochrome complex P450:.. Warfarin and other anticoagulants, carbamazepine, theophylline, astemizole, cisapride, triazolam, midazolam, cyclosporin, digoxin, ergot alkaloids, etc., reduce the absorption of zidovudine . Dosage and administration: Inside, not liquid, squeezed small amounts of liquid. Adults and children over 12 years - 250 mg every 12 hours; sinusitis, severe infections, including caused by H.influenzae, - 500 mg every 12 hours; the maximum daily dose of 2 children up to 12 years - 7.5 mg / kg of body weight every 12 hours; the maximum daily dose of 500 mg. The course of treatment - 7-14 days. In patients with renal insufficiency recommended single dose of 250 mg per day (for severe infections - 250 mg 2 times daily) (Cl in creatinine less than 30 ml / min or serum creatinine concentration of 3.3 mg / 100 ml). Biaxin half life Precautions: Be wary appointed on a background of drugs metabolized by the liver (it is recommended to measure their concentration in the blood). In the case of combination with warfarin or other. Indirect anticoagulants is necessary to monitor the prothrombin time. When heart disease in history is not recommended simultaneous with terfenadine, cisapride, astemizole.
Category: buy biaxin xl online | Added by: Dnister (08.10.2016)
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